Autoinducer-2-mediated communication network within human gut microbiota.

ABSTRACT: Quorum sensing (QS) is a chemical communication process that connects microbial members in various microbial systems. Bacterial communication networks mediated by QS play important roles in the regulation of intestinal microecological balance as well as nutrition and metabolism of the host. However, how human gut microbes utilize QS signals to communicate with one another remains largely unknown. In this study, we first examined the prevalence and abundance of genes encoding QS signal synthases in 3329 species representatives clustered from 289232 prokaryotic genomes in the Unified Human Gastrointestinal Genome collection. Our results show autoinducer-2 (AI-2) is the most prevalent QS signal within the human gut microbiota, with the synthase gene luxS being found in 2039 species mainly dis

SUBMITTER: Fan Q 

PROVIDER: S-EPMC12503165 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature