Integrated analysis of ARHGAP6 potential function and prognostic value in acute myeloid leukemia.

ABSTRACT:

Background

Leukemia recurrence continues to be the primary cause of treatment failure, it is meaningful to find new biomarkers for its treatment. In this study, we aim to use cell line study to assess the expression and prognostic value of ARHGAP6 in acute myeloid leukemia.

Methods

We applied two acute myeloid leukemia cell lines in the research. Expression level, proliferation assay and apoptosis assay for ARHGAP6 in those cell lines were involved for the study. Then, GEO, TCGA data and bioinformatics analysis were evaluated.

Results

THP-1 and U937 cell lines both had higher expression levels of ARHGAP6 than control. The cell proliferation of THP-1 and U937 transfected with ARHGAP6 siRNA was significantly reduced. Knock down the gene ARHGAP6 increases AML cell apopto

SUBMITTER: Yang D 

PROVIDER: S-EPMC12503237 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature