Dose-response and isotemporal substitution analysis of domain-specific physical activity and sedentary behavior with abdominal aortic calcification risk: A cross-sectional study.

ABSTRACT:

Background

Abdominal aortic calcification (AAC) is an independent risk factor for cardiovascular disease. This study aims to examine the dose-response relationships between domain-specific moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and AAC risk, and the effects of time reallocation among these behaviors, in individuals aged 40 years and older.

Methods

This cross-sectional study used data from NHANES participants from the 2013-2014 cycle. MVPA and SB were self-reported, and AAC status was assessed using the Kauppila scoring system and DXA. Weighted logistic regression calculated odds ratio (OR) and 95% confidence interval (CI) for dose-response relationships, using restricted cubic splines (RCS). Furthermore, weighted logistic regression models wi

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12503245 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature