A novel TRPV5/6-like channel from a scleractinian coral.

ABSTRACT: The calcium regulation mechanisms that underlie skeleton formation in stony corals are poorly understood. In epithelial tissues from vertebrates, transient receptor potential vanilloids 5 and 6 (TRPV5 and TRPV6), members of the TRP channel superfamily, play a significant role in transepithelial Ca2+ transport. Particularly, TRPV5 is a constitutively active channel with a primary function in the Ca2+ reabsorption mechanism of renal epithelium. It is characterized by a marked inward rectification and a high Ca2+ permeability at physiological resting membrane potentials. Here, we report the cloning and characterization of a gene that encodes a protein homologous to the inward-rectifier cation channel TRPV5 in the reef-building coral Pocillopora damicornis. We assessed its biophysical properti

SUBMITTER: Mendez-Resendiz A 

PROVIDER: S-EPMC12503276 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature