Sensory appendage protein triggers alarm to pyrethroid in Indian malarial vector Anopheles culicifacies.

ABSTRACT: Sensory appendage proteins (SAPs), members of the odorant-binding protein family, mediate chemical communication that is vital for mosquito survival and vector competence. Among the six identified SAP members, AcSAP1 and AcSAP2 exhibited dominant expression in olfactory and leg tissues of Anopheles culicifacies. Our findings reveal that the expression of AcSAP1, and to a lesser extent AcSAP2, is significantly modulated by the circadian rhythm, with peak expression coinciding with the nocturnal host-seeking behavior of female mosquitoes. A delayed host attraction response by the AcSAP1-silenced female mosquitoes accounts for AcSAP1's potential role in host-seeking activities. In silico prediction data showed strong binding affinity to synthetic pyrethroid (deltamethrin); therefore, we teste

SUBMITTER: Saini V 

PROVIDER: S-EPMC12503281 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature