Non-invasive brain stimulation paradigms in treatment of alcohol use disorder: Systematic review and network meta-analysis protocol.

ABSTRACT:

Background

Alcohol use disorder (AUD) is a chronic condition linked to allostatic neuroadaptations in the brain's reward circuitry, leading to compulsive and automatized alcohol use in response to craving or negative affect. There are only a few treatment options for AUD, and their efficacy and tolerance profiles remain suboptimal. New AUD management strategies are actively being investigated, and among these, non-invasive brain stimulation (NIBS) interventions. We are planning to conduct a systematic review and network meta-analysis to simultaneously compare different NIBS strategies for AUD, and the present protocol aims to document our methodological approaches and a priori decisions.

Methods and analysis

We will include only randomized controlled trials involving adults

SUBMITTER: Demina A 

PROVIDER: S-EPMC12503284 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature