Plasma membrane recycling drives reservoir formation during Toxoplasma gondii intracellular replication.

ABSTRACT: During intracellular development, apicomplexan parasites reside within a parasitophorous vacuole largely derived from the host plasma membrane (PM) and rendered nonfusogenic with the host endolysosomal system. Yet, the parasite is capable of protein uptake from the host cell via endocytosis, which occurs via a conserved structure, the micropore. Recently the composition of the micropore was characterized and its stability was shown to depend on the presence of the kelch-domain protein K13 which is also central to malarial drug-resistance to artemisinin. Interestingly, depletion of K13 also resulted in an impressive accumulation of PM attached to or between individual parasites, suggesting that the micropore plays a critical role in PM homoeostasis. Here, we characterized the dynamics and r

SUBMITTER: von Knoerzer-Suckow J 

PROVIDER: S-EPMC12503318 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature