Histopathological change of age-related hearing loss in female advance-aged CBA/CaJ mice.

ABSTRACT: With the increase in the older population, the number of individuals with age-related hearing loss is also growing explosively. Therefore, there is an urgent need to identify the detailed pathology of age-related hearing loss and develop novel treatment strategies. In this study, we have investigated the audiological physiology and cochlear pathology of advanced-age CBA/CaJ mice, a strain that resists early pathological hearing loss. The subjects were naturally aged close to their lifespan limit (> two years) under normal in vivo conditions. We used 11 CBA/CaJ mice aged between 129 and 138 weeks to establish an aged group. To compare the electrophysiological function and histological changes, a young group was established using 12 young mice aged between 9 and 14 weeks. The loss of outer h

SUBMITTER: Inuzuka Y 

PROVIDER: S-EPMC12503338 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature