ABSTRACT: The global industry of tobacco (Nicotiana tabacum L.) is a profitable one comprising various products, including cigars, cigarettes, chewing tobacco, and smokeless tobacco. The internal quality of the cigarettes is highly related to the chemical components of tobacco leaves and shreds. Blue mold severity (BMS), chlorophyll (Chl), total nitrogen (N), sugar (S), nicotine (Nt), chloride (Cl), and potassium (K) contents of tobacco leaves are linked to the flavor and taste of cigarette products. A precise analysis of the effects of these factors would open the door for improving farmer income in low- and middle-income countries. In this study, BMS, Chl, N, S, Nt, Cl, K, green weight (GW), dry weight (DW), and leaf quality of four cultivars, including Bergerac, Bell, Burly, and Basma, were evalu