Polysaccharide from <i>Trichosanthes kirilowii</i> Maxim ameliorates diphenoxylate-induced functional constipation in mice.

ABSTRACT:

Introduction

Trichosanthes kirilowii Maxim has been well-documented for its pharmacological effects in alleviating constipation. Notably, polysaccharides, a class of natural macromolecules, demonstrate significant therapeutic potential for constipation management. Nevertheless, the preventive effect of Trichosanthes kirilowii polysaccharide (TKP) against functional constipation and its underlying mechanisms remain poorly understood.

Methods

In this study, a mouse model of diphenoxylate-induced functional constipation was established. Meanwhile, the laxative effect of TKP on the fecal excretion function, intestinal inflammatory response, neurotransmitter secretion and gut microbiota composition were evaluated.

Results

Treatment with the TKP alleviated the

SUBMITTER: Jiang M 

PROVIDER: S-EPMC12503411 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature