Association of Localized Retinal Sensitivities with Spectral-Domain Optical Coherence Tomography-Derived Morphologic Data in Macular Subfields in Age-Related Macular Degeneration.

ABSTRACT:

Introduction

This study investigated microperimetry-derived retinal sensitivity and optical coherence tomography (OCT)-based macular morphologic data in eyes with early and intermediate age-related macular degeneration (AMD). The respective metrics were compared between macular subfields and their associations were determined. Detailed knowledge of functional associations with morphology is an asset to future therapeutic trial design.

Methods

This is a cross-sectional analysis of microperimetry and spectral-domain OCT baseline data. OCT data were segmented automatically within the HEYEX software (Heidelberg Engineering). Data were assessed for Gaussian normal distribution by the D'Agostino and Pearson tests, and appropriate comparison tests were performed for parametric and

SUBMITTER: Marques IP 

PROVIDER: S-EPMC12503456 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature