Dihydroquercetin/Taxifolin Inhibits METTL3/m⁶A/PIM2 Expression by Suppressing RIPK2 Phosphorylation Mediated NF-κB p65 Signaling Pathway to Alleviates Renal Ischemia-Reperfusion Injury in Mice.

ABSTRACT:

Introduction

There is a close relationship between oxidative stress and renal ischemia-reperfusion injury (RIRI). Dihydroquercetin (DHQ, also known as Taxifolin) can reduce kidney damage, and suppress cellular damage caused by oxidative stress. This study aimed to investigated the effects and underlying mechanisms of DHQ on RIRI.

Methods

First, hypoxia/reoxygenation (H/R) treated HK-2 cells were used for RIRI in vitro experiments, and the dosage of DHQ was selected by observing cell viability and lactate dehydrogenase release. The protective effects of DHQ were evaluated by detecting cell apoptosis, reactive oxygen species (ROS) levels, and oxidative stress indicators levels.

Results

Our data suggested that DHQ inhibited cell apoptosis, ROS levels, and oxidative stres

SUBMITTER: Shen S 

PROVIDER: S-EPMC12503484 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature