Distributed subthreshold representation of sharp wave-ripples by hilar mossy cells.

ABSTRACT: In neural information processing, the nervous system transmits neuronal activity between layers of neural circuits, occasionally passing through small layers composed only of sparse neurons. Hippocampal hilar mossy cells (MCs) constitute such a typical bottleneck layer. However, how efficient information encoding is achieved within such constrained layers remains poorly understood. To address this, we focused on sharp wave-ripples (SWRs) - synchronous neural events originating in the CA3 region - and investigated functional diversity within MC populations using in vivo/in vitro patch-clamp recordings in mice. By combining machine learning algorithms, we developed a model to predict CA3 SWR waveforms based on the synaptic response waveforms of MCs, suggesting that SWR-related information is

SUBMITTER: Ouchi A 

PROVIDER: S-EPMC12503485 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature