Increased Risk of Heart Failure among Patients with Bullous Pemphigoid: A Nationwide Cohort Study.

ABSTRACT:

Introduction: Bullous pemphigoid (BP) and heart failure (HF) share similar mechanisms involving chronic inflammation. Nevertheless, the association of BP with HF has been unclear. This study aimed to investigate the association of BP with incident HF.

Methods

We conducted a nationwide cohort study included adults aged ≥20 years from Taiwan's National Health Insurance Research Database between 2011 and 2019. Adults with newly diagnosed BP and matched controls were included. A Cox regression model considering stabilized inverse probability weighting was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident HF in association with BP. Stratified analyses according to age and sex were conducted. Multiple sensitivity analyses were also performed.

Resul

SUBMITTER: Chen TL 

PROVIDER: S-EPMC12503501 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature