Photoinduced Pd-Catalyzed Direct Sulfonylation of Allylic C-H Bonds.

ABSTRACT: Allylic sulfones are valuable motifs due to their medicinal and biological significance and their versatile chemical reactivities. While direct allylic C-H sulfonylation represents a straightforward and desirable approach, these methods are primarily restricted to terminal alkenes, leaving the engagement of the internal counterparts a formidable challenge. Herein we report a photocatalytic approach that accommodates both cyclic and acyclic internal alkenes with diverse substitution patterns and electronic properties. Importantly, the obtained allylic sulfones can be readily diversified into a wide range of products, thus enabling formal alkene transposition and all-carbon quaternary center formation through the sequential C-H functionalization.

SUBMITTER: Mukherjee K 

PROVIDER: S-EPMC12503507 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature