Direct Hemoperfusion with Polymethylmethacrylate for Hemodialysis Patients with Dialysis-Related Amyloidosis.

ABSTRACT:

Introduction

Dialysis-related amyloidosis (DRA) is a serious complication in patients undergoing long-term dialysis that leads to conditions such as carpal tunnel syndrome and destructive spondyloarthropathy. Improved removal of the precursor protein β₂-microglobulin (β₂-m) is considered an effective treatment strategy for DRA. Polymethylmethacrylate (PMMA) membranes have the capacity to adsorb β₂-m in dialysis filters, suggesting that direct hemoperfusion with PMMA in addition to standard dialysis may enhance β₂-m removal.

Methods

This prospective cohort study included 10 patients undergoing hemodialysis, who were diagnosed with DRA. The participants were treated with dialysis filter alone during visit 1, both standard dialysis fi

SUBMITTER: Yamazaki S 

PROVIDER: S-EPMC12503591 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature