Nasopharyngeal Carcinoma Presenting with Extensive Osseous Metastases and Intracranial Involvement: A Case Report.

ABSTRACT:

Introduction

Nasopharyngeal carcinoma (NPC) rarely presents with extensive osseous metastases and intracranial involvement as initial manifestations, posing diagnostic challenges. This report details an unusual case, highlighting its unique clinical course and the importance of considering NPC in atypical metastatic presentations, particularly when an association with Epstein-Barr virus (EBV) is identified.

Case presentation

An approximately 60-year-old female presented with a progressively enlarging forehead lesion, headaches, and subsequent findings of calvarial lytic lesions with intracranial extension. Comprehensive imaging (MRI, computed tomography [CT], PET/CT) revealed extensive fluorodeoxyglucose-avid osseous metastases and identified a hypermetabolic primary mass in

SUBMITTER: Marrero Castillo M 

PROVIDER: S-EPMC12503601 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature