Acute Mood Episodes in Patients of Atopic Dermatitis Treated with Dupilumab: Insights from two Cases.

ABSTRACT:

Introduction

Atopic dermatitis (AD) is a chronic skin disease that can affect patients' quality of life through a recurrent inflammatory skin condition, which is often associated with psychiatric effects including depression and anxiety. Treatment with biologics such as dupilumab, an anti-IL-4 receptor alpha antibody, is an effective treatment of AD for both resolving skin conditions and reducing the risk of psychiatric comorbidities. However, the impact of its systemic effects on rare types of patients who are predisposed to psychiatric conditions are not fully understood.

Case presentations

We report 2 cases of AD patients who experienced acute mood episodes during the treatment with dupilumab. While showing remarkable improvement in their skin condition and itch, both pat

SUBMITTER: Sasaki G 

PROVIDER: S-EPMC12503642 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature