A Case of Chronic Active T-Cell-Mediated Rejection Caused by Plasma Cell-Rich Acute Rejection 12 Years after Kidney Transplantation.

ABSTRACT:

Introduction

Plasma cell rich-acute rejection (PCAR) is a variant of T-cell-mediated rejection in kidney transplantation. Its pathogenesis remains unknown and it is often refractory to standard immunosuppression strategies, possibly leading to allograft loss. Here, we report a case of chronic active T-cell-mediated rejection caused by PCAR 12 years after kidney transplantation.

Case presentation

A patient first visited our outpatient clinic with hematuria and proteinuria at the age of 23. He was followed as an outpatient for suspected chronic glomerulonephritis, but his kidney function gradually deteriorated and hemodialysis was initiated at age 50. ABO-compatible kidney transplantation was performed at 51. His graft function was stable for 11 years post-transplant with a se

SUBMITTER: Hayashi A 

PROVIDER: S-EPMC12503644 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature