Immunological Profile of Patients with Rheumatoid Arthritis and Asthma.

ABSTRACT:

Introduction

The aim of this study was to investigate cytokine profiles in patients with both rheumatoid arthritis (RA) and bronchial asthma (BA).

Methods

We studied 25 patients with RA, 25 with BA, and 25 with both RA and BA (BARA). A respiratory questionnaire was completed by all the patients, they underwent spirometry, and their production patterns of selected T helper (Th)1, Th2, and Th17 cytokines were assessed.

Results

BA patients had spirometry findings similar to BARA patients, while RA patients had normal spirometry. BA patients produced significantly higher levels of interleukin (IL)-5 (p = 0.03) and IL-10 (p = 0.03) than patients with RA. Median levels of IL-17A and IL-17F and interferon (IFN)-γ were higher (p = 0.001, 0.004, and 0.04) in RA patients than i

SUBMITTER: Almutairi SS 

PROVIDER: S-EPMC12503720 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature