HOOK1 Gene Expression and DNA Methylation in Obesity and Related Cardiometabolic Traits.

ABSTRACT:

Introduction: Accumulation of fat in omental visceral adipose tissue (OVAT) is strongly linked to metabolic diseases. Our recent findings show a distinct and more accessible chromatin landscape of the visceral depot compared to its subcutaneous counterpart. Based on integrated analysis of chromatin accessibility and transcriptomics, we identified previously unrecognised genes linked with obesity. Here, we performed in-depth analyses of one of the candidates, HOOK1, and tested for depot-specific gene expression, correlation with clinical traits and regulatory mechanisms including DNA methylation.

Methods

We utilised intra-individually paired adipose tissue samples of human OVAT and subcutaneous adipose tissue (SAT) from our in-house cohort (N = 78). Gene expression was measured us

SUBMITTER: Svensson SIA 

PROVIDER: S-EPMC12503723 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature