Severe Hypercalcemia in a Patient with Chronic Lymphocytic Leukemia following Treatment Disruption.

ABSTRACT:

Introduction

Hypercalcemia is a common paraneoplastic syndrome rarely seen in chronic lymphocytic leukemia (CLL). When it occurs, it often signals disease progression or Richter transformation. Disruption of cancer care in conflict zones may contribute to worsening clinical outcomes.

Case presentation

We report a 63-year-old Arab female with a 3-year history of CLL, previously treated with chlorambucil and rituximab, who developed severe hypercalcemia (total calcium 19.9 mg/dL) after an 8-month interruption of chemotherapy due to transportation barriers amid regional conflict. She presented with confusion, weakness, polyuria, and polydipsia. Laboratory evaluation showed suppressed parathyroid hormone, normal vitamin D, renal impairment, and no evidence of lytic bone lesions.

SUBMITTER: Al-Bitar A 

PROVIDER: S-EPMC12503726 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature