Choroidal Neovascularization following Intra-Arterial Melphalan Chemotherapy for Retinoblastoma.

ABSTRACT:

Introduction

We present the unique case of a pediatric patient who underwent intra-arterial melphalan chemotherapy and subsequently developed choroidal neovascularization.

Case presentation

A 6-year-old male with a history of nonhereditary unilateral group D retinoblastoma treated with intra-arterial melphalan, cryotherapy, and diode laser consolidative therapy presented to establish care. Initial evaluation revealed a regressed retinoblastoma lesion with chorioretinal scars and calcification scattered in the midperiphery. Notably, the macula was largely within normal limits without evidence of prior malignancy or scarring. However, 7 months after establishing care, imaging was significant for intraretinal fluid, subretinal fluid, and subfoveal fibrosis of the treated eye, s

SUBMITTER: Amani N 

PROVIDER: S-EPMC12503736 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature