Causal Associations of Gestational and Perinatal Factors with the Risk of Childhood Obesity: A Mendelian Randomization Study.

ABSTRACT:

Introduction: This study was to explore the causal association between gestational and perinatal factors and the risk of childhood obesity based on two-sample Mendelian randomization (MR).

Methods

The single-nucleotide polymorphisms (SNPs) associated with exposure were selected. MR Egger regression was used for the evaluation of the horizontal pleiotropy in SNPs. F-statistic reflects the strength of instrumental variables. Cochran's Q statistic was used to investigate the heterogeneity of SNPs. The primary MR method exploring the causal association between gestational and perinatal factors and the risk of childhood obesity was inverse variance weighted (IVW). Leave-one-out analysis was employed to identify whether the MR results were affected by single SNPs. Odds ratio (OR) and 9

SUBMITTER: Lin S 

PROVIDER: S-EPMC12503751 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature