Possible Treatment of Topical Steroid Withdrawal with Methylene Blue Case Report: Implications for Mitochondrial Pathology.

ABSTRACT:

Introduction

Recent observations have demonstrated that topical steroid withdrawal (TSW) is an induced, but targetable, defect in mitochondrial complex I function that warrants further investigation.

Case presentation

An 8-year-old girl with atopic dermatitis (AD) was treated with topical corticosteroids (TCSs), including high-potency agents. Her initial symptoms were limited to the chest and back. After approximately 3 months of treatment with escalating potency, the perceived lack of TCS efficacy prompted her parents to discontinue TCS while maintaining emollients. Four weeks later, the patient developed new symptoms consistent with TSW involving the face, neck, and legs. The family attempted alternative-medical treatments including turmeric, vitamin D3, and more without c

SUBMITTER: Jordan J 

PROVIDER: S-EPMC12503774 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature