Visual Recovery in Leber's Hereditary Optic Neuropathy Plus: A Case Report and Literature Insight.

ABSTRACT:

Introduction

Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder that primarily affects young men, leading to subacute, painless, bilateral loss of central vision. It is caused by point mutations in mitochondrial DNA, especially those involving the MT-ND1, MT-ND4, and MT-ND6 genes, which disrupt complex I function in the mitochondrial respiratory chain.

Case presentation

We describe an 18-year-old male cricket player who presented with a 6-month history of gradually worsening, painless visual loss in both eyes. His best corrected visual acuity was 6/60 in the right eye and 3/60 in the left eye. Color vision was reduced in the left eye but improved when tested with a red filter, raising suspicion of optic nerve path

SUBMITTER: Paranjpe R 

PROVIDER: S-EPMC12503776 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature