Predictive Performance of HAS-BLED Score in Patients with Atrial Fibrillation and Cancer: A Meta-Analysis.

ABSTRACT:

Introduction

Patients with atrial fibrillation (AF) and history of cancer face unique bleeding risks, complicating the applicability of standard bleeding risk scores like HAS-BLED. This meta-analysis aimed to evaluate the performance of HAS-BLED in predicting bleeding events in this high-risk population.

Methods

The MEDLINE, PubMed, and EMBASE databases were searched from 1st of January 2010 to 30th of November 2024 for relevant studies using keywords, such as "AF" "cancer" "bleeding," and "HAS-BLED." Data on C-statistics were extracted to assess the predictive performance of HAS-BLED score.

Results

Our analysis included seven retrospective cohort studies, recruiting a total of 436,102 patients. The quality of the included studies was deemed acceptable for analysis. T

SUBMITTER: Ajabnoor AM 

PROVIDER: S-EPMC12503809 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature