Mapping Disease Burden of Major Depressive Disorder and Its Risk Factors in Low- and Middle-Income Countries.

ABSTRACT:

Introduction

Major depressive disorder (MDD) is currently the second leading cause of life expectancy due to disability globally. This study aimed to examine the disease burden, risk factors, and temporal trends of MDD in low- and middle-income countries (LMICs) from 1990 to 2021.

Methods

Disability-adjusted life years (DALYs) data for 135 LMICs were obtained from the 2021 Global Burden of Disease (GBD) database. To assess trends in the burden of MDD over the past 3 decades, segmented regression analysis was applied to calculate the estimated annual percentage change. Spearman correlation analysis was conducted to examine the association between gross national income (GNI) and gender disparities in age-standardized DALY rates (ASDR) for MDD. We also explored how key risk fac

SUBMITTER: Yu Q 

PROVIDER: S-EPMC12503812 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature