Identification of Hypoxia-Related Genes in Human Myocardial Infarction and Cancers.

ABSTRACT:

Introduction

Myocardial infarction (MI) and cancer collectively account for over 50% of global mortality. Recent studies have revealed multiple associations between these two diseases, including chronic inflammation and oxidative stress, with particular focus on hypoxia-mediated signaling pathways. In ischemic myocardium, oxygen deprivation triggers apoptosis, fibrosis, and pathological tissue reorganization; in the tumor microenvironment (TME), hypoxia drives angiogenesis, metabolic reprogramming, and immune evasion. Thus, identifying differentially expressed genes related to hypoxia in MI may provide new targets for the treatment of MI and cancer.

Methods

The specimens from MI patients in this study were retrieved from the Gene Expression Omnibus (GEO) database. Using the

SUBMITTER: Yan S 

PROVIDER: S-EPMC12503813 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature