Plasma and Urinary KIM-1 in Chronic Kidney Disease: Prognostic Value, Associations with Albuminuria, and Implications for Kidney Failure and Mortality.

ABSTRACT:

Introduction

Kidney injury molecule-1 (KIM-1) expression reflects proximal renal tubular damage, but plasma and urine KIM-1 have not been jointly studied in a CKD cohort.

Methods

Plasma and urine KIM-1 were measured in 2,581 adults from the NURTuRE-CKD cohort, a multicentre, non-dialysis-dependent CKD cohort. Survival analyses, C-statistics, and net reclassification improvement were used to assess associations and predictive performance of plasma and urine KIM-1 for kidney failure (KF), all-cause mortality, and a secondary endpoint of combined CKD progression endpoint (CKE) (KF or >40% decline in eGFR) in the total cohort and in KDIGO albuminuria categories, early CKD (eGFR >45 mL/min/1.73 m2), and four plasma/urine KIM-1 groups, dichotomised above and below the median value

SUBMITTER: McDonnell T 

PROVIDER: S-EPMC12503817 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature