Reaction of N-Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo.

ABSTRACT: Electron-deficient aminoferrocenes (edAFs) exhibit anticancer activity both in vitro and in vivo. However, their mechanism of action remains unclear. Studies using fluorogenic edAF derivatives suggest that the ferrocenyl moiety undergoes oxidation or decomposition within cells, resulting in the formation of unknown products. Interestingly, this process is not significantly facilitated by H₂O₂, indicating that this intracellular oxidant does not alter edAFs in the cellular environment. To identify alternative endogenous oxidants, NO is investigated as a potential candidate. Under aerobic conditions, NO is found to efficiently induce the oxidation and decomposition of edAFs. This transformation is mediated by an electrophilic nitrosation reaction, followed by nitroso-ox

SUBMITTER: Selin R 

PROVIDER: S-EPMC12503903 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature