Quantitative ¹³C-urea breath test values predict peptic ulcer risk in <i>Helicobacter pylori</i> -infected children: a retrospective study.

ABSTRACT:

Background

The quantitative ¹³C-urea breath test (¹³C-UBT) is valuable for diagnosing Helicobacter pylori (H. pylori) infection. However, pediatric-specific thresholds and their association with peptic ulcer (PU) disease remain inadequately defined. This study aimed to identify optimal pediatric delta over baseline (DOB) thresholds for diagnosing H. pylori infection and explore associations with ulcer risk in children.

Methods

In this retrospective study, 1,034 consecutive children aged 3-18 years undergoing ¹³C-UBT with endoscopy and histopathological evaluation at Fujian Children's Hospital (May 2021-May 2025) were enrolled. DOB cutoff values were determined by ROC analysis. Logistic regression and restricted cubic spline (RCS) analyses evaluated associations betwee

SUBMITTER: Pan X 

PROVIDER: S-EPMC12504025 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature