Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial.

ABSTRACT:

Introduction

We examined whether participant characteristics, including sociodemographics, APOE ε4 allele, lifestyle factors, and cardiovascular risk factors, modified the effect of the Mediterranean-Dietary Approach to Systolic Hypertension Intervention for Neurodegenerative Delay (MIND).

Methods

The MIND trial (NCT02817074) randomized adults 65 to 85 years who were overweight or obese to the MIND diet or control diet conditions. A linear mixed-effects model was used to examine whether participant characteristics modified the effect of MIND on the annual change in a global cognition score derived from a battery of 12 neurocognitive tests.

Results

On average, participants (N = 604) were 70.4 years old, 65.5% female, and with a body mass index (BMI) of 33.9 kg/m^2<

SUBMITTER: Halloway S 

PROVIDER: S-EPMC12504047 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature