Association of dietary sodium intake with late-life cognitive decline and postmortem neuropathology in community-dwelling older adults.

ABSTRACT:

Introduction

Studies link sodium intake to cognition, but most were cross-sectional, and associations with neuropathology remain unclear.

Methods

1520 community-dwelling adults (mean age 80.7 years) had annual evaluations (mean follow-up 7.6 years), including 19 neuropsychological tests and a food frequency questionnaires (FFQ). Postmortem neuropathologies were documented in 717 deceased participants. Associations of dietary sodium intake estimated from the FFQ with cognitive decline and neuropathology were examined using adjusted regression models.

Results

Compared to the middle sodium intake quintile (median 2264 mg/day), the lowest quintile (1764 mg/day), but not the highest (2800 mg/day), was associated with faster decline in global cognition, particularly episodi

SUBMITTER: Tong H 

PROVIDER: S-EPMC12504065 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature