A comparison of five different drug-drug interaction checkers for selective serotonin reuptake inhibitors.

ABSTRACT:

Background

Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for depression and anxiety, but their potential for drug-drug interactions (DDIs) poses significant risks, particularly given their influence on cytochrome P450 enzymes. Variability in identifying and classifying these interactions among drug interaction checkers (ICs) can complicate clinical decision-making and compromise patient safety. This study aims to compare five widely used ICs in identifying DDIs related to SSRIs, highlighting discrepancies in DDI identification and severity classification to inform best practices.

Methods

A comparative study was conducted using five popular ICs (Micromedex, Lexi-Interact, Epocrates, Medscape, and Drugs.com) to evaluate their performance in identifying

SUBMITTER: Xu S 

PROVIDER: S-EPMC12504084 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature