Trends in adolescent pertussis burden: a systematic analysis from 1990 to 2021 in global, regional, and national within the global burden of disease study 2021, with forecasts for 2046.

ABSTRACT:

Background

Pertussis, a highly contagious respiratory disease caused by Bordetella pertussis, traditionally associated with children, is now increasingly transmitted by adolescents (ages 10-19) and adults. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021), we estimated the disease burden of pertussis among adolescents.

Methods

We analyzed adolescent pertussis data from GBD 2021, assessing prevalence, incidence, mortality, and Disability-Adjusted Life Year (DALY) rate across global, regional, and national levels. Temporal trends were quantified with the Estimated Annual Percentage Change (EAPC), and decomposition and prediction models were employed for further insights.

Results

From 1990 to 2021, adolescent pertussis preval

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12504105 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature