A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison.

ABSTRACT: Major depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studies have, so far, not been widely replicated, suggesting a need for larger meta-analysis studies. Here we conducted a meta-analysis of methylome-wide association analysis for lifetime MD across 18 studies of 24,754 European-ancestry participants (5,443 MD cases) and an East Asian sample (243 cases, 1,846 controls). We identified 15 CpG sites associated with lifetime MD with methylome-wide significance. The methylation score created using the methylome-wide association analysis summary statistics was significantly associated with MD status in an out-of-samp

SUBMITTER: Shen X 

PROVIDER: S-EPMC12504109 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature