M⁶A RNA Modification Controls HTLV-1 Tax and Host Gene Expression.

ABSTRACT: Human T-cell Leukemia Virus Type 1 (HTLV-1) is a pathogenic human retrovirus that is responsible for intractable diseases such as adult T-cell leukemia-lymphoma (ATL), a malignancy with a poor patient prognosis. Although recent studies have delineated several genomic, epigenomic, and transcriptomic abnormalities associated with HTLV-1, to date the importance of epitranscriptomic modifications, particularly N⁶-methyladenosine (m⁶A), remains unclear. Here, we showed that the HTLV-1 RNA genome undergoes m⁶A modification, thereby suggesting that these modifications act as bidirectional regulators of both viral and host processes. Moreover, targeted depletion of m⁶A modification within the viral transactivator HTLV-1 Tax resulted in markedly destabili

SUBMITTER: Gibu R 

PROVIDER: S-EPMC12504147 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature