Novel inducible nitric oxide synthase-inhibiting cytochalasins from an oyster-derived fungus Westerdykella dispersa Ca4-13: structural insights and molecular docking analysis.

ABSTRACT:

Background

Marine-derived microorganisms are renowned for producing structurally diverse secondary metabolites with notable biological activities, serving as a promising reservoir for pharmaceutical development. In this study, the fungal strain Westerdykella dispersa Ca4-13, isolated from the edible oyster Crassostrea angulata, was investigated for its potential anti-inflammatory and cytoprotective properties using BV-2 microglial cells as a model system.

Results

Metabolite profiling of the solid-state fermented products of W. dispersa Ca4-13 yielded seven compounds 1-7. Their structures were elucidated using NMR and MS techniques, revealing three previously undescribed cytochalasins, namely westerchalasin A (1), westerchalasin B (2), and westerchalasin C (3), along with fou

SUBMITTER: Huang SJ 

PROVIDER: S-EPMC12504155 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature