Deficient DNA mismatch repair and Nectin-4 expression in upper tract urothelial carcinoma (UTUC).

ABSTRACT:

Purpose

To investigate the prevalence of deficient DNA mismatch repair (dMMR) status in upper tract urothelial carcinoma (UTUC) and its association with clinicopathological characteristics as well as Nectin-4 immunohistochemical expression.

Methods

We retrospectively identified histologically confirmed UTUC cases treated at Peking University Third Hospital between December 2016 and September 2023. Eligible participants were required to also possess complete clinicopathological records and available formalin-fixed, paraffin-embedded (FFPE) tumor specimens suitable for immunohistochemical evaluation. MMR protein expression was categorized as either dMMR or proficient mismatch repair (pMMR), while Nectin-4 expression was quantitatively assessed using the H-score system. Samples

SUBMITTER: Duan P 

PROVIDER: S-EPMC12504161 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature