Altered plasma fatty acids composition in autism spectrum disorder: a case-control study.

ABSTRACT:

Background

Due to the variability in clinical manifestations and the frequent diagnostic delays associated with autism spectrum disorder (ASD), interest in identifying fatty acids as potential biomarkers is increasing. Nonetheless, owing to inconclusive evidence, further investigation is needed.

Objective

To explore the relationship between fatty acids and ASD risk and identify distinct fatty acid metabolites in children with ASD.

Methods

Plasma fatty acid levels were tested in totally 131 participants (ages 2-6 and male-to-female ratio 2.5:1) with and without ASD using gas chromatography coupled to flame ionization detector and mass spectrometer (GC-FID/MS) technology. Between-group differences in each fatty acid and the omega-3 polyunsaturated fatty acid/arachidonic

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12504180 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature