Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy.

ABSTRACT:

Background

Acteoside (ACT), a natural phenylethanoid glycoside extracted from the Rehmannia glutinosa, has demonstrated renal protective effects against diabetic nephropathy (DN) through its confirmed antioxidant and anti-inflammatory properties. However, the underlying mechanisms by which ACT regulates DN progression via targeting ferroptosis remain to be elucidated.

Purpose

This study aims to elucidate whether ACT ameliorates DN in mice by targeting ferroptosis and to uncover the underlying mechanisms involved.

Methods

This study first utilized network pharmacology approaches, integrating multiple databases and bioinformatics tools, to predict and screen the potential targets and pathways of ACT in DN. To validate the therapeutic efficacy of ACT, a DN model w

SUBMITTER: Luo Z 

PROVIDER: S-EPMC12504188 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature