Exercise-induced modulation of gut microbiota in individuals with obesity and type 2 diabetes: a systematic review and meta-analysis.

ABSTRACT:

Objective

This systematic review and meta-analysis aimed to evaluate the effects of exercise on gut microbiota in individuals with obesity and type 2 diabetes (T2D), including alpha-diversity indices (Shannon, Simpson, Chao1, and observed OTUs) and taxonomic composition, to explore the potential role of gut microbiota in mediating the effects of exercise on disease progression.

Methods

A total of 19 studies comprising 1,062 participants were included. Alpha-diversity indices and taxonomic changes were analyzed using meta-analysis and qualitative synthesis. Subgroup analyses were conducted based on exercise type and age.

Results

Meta-analysis showed that exercise significantly increased the Shannon index in both the obesity group (SMD = 0.40 [0.15, 0.65], P = 0.

SUBMITTER: Lin W 

PROVIDER: S-EPMC12504204 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature