Insecticidal activity of the linear pseudoscorpion venom peptide Ammogarypin revealed by functional profiling.

ABSTRACT: Some pseudoscorpions produce venom to subdue prey and their venom components may be of translational interest in agronomy and beyond. However, only very few pseudoscorpion venom peptides have been functionally characterized as of yet. Here, we carry out a bioactivity profiling of Ammogarypin, a linear venom peptide recently identified in the venom of Ammogarypus lawrencei. We show, that the peptide causes signs of spastic paralysis and fatalities when injected in Drosophila suzukii flies and low toxicity when injected in Myzus persicae aphids, while no effects were recovered when fed to both insects. The toxin further has marginal effects on growth of E. coli and S. aureus bacteria and no effect on the viability of mammalian MDCKII cells and equine erythr

SUBMITTER: Pierry M 

PROVIDER: S-EPMC12504284 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature