Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study.

ABSTRACT:

Objective

Peritoneal dialysis (PD) patients demonstrate distinct iron homeostasis imbalances. However, the relationship between brain iron and cognitive impairment in this population remains poorly elucidated.

Methods

This study enrolled 52 PD patients and 49 healthy controls (HCs). Quantitative susceptibility mapping (QSM) was employed to quantify cerebral iron deposition. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and a comprehensive neuropsychological test battery. Dose-response relationships between iron metabolism parameters and cognitive performance were analyzed using generalized additive models (GAMs).

Results

PD patients exhibited significantly higher iron deposition in the left amygdala and right putamen compared to HCs. S

SUBMITTER: Li D 

PROVIDER: S-EPMC12504288 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature