Integrative analysis of serum microorganisms and serum metabolomics in osteoporosis patients based on 16S rDNA sequencing and UHPLC/MS-based metabolomics.

ABSTRACT:

Introduction

Although significant progress has been made in the treatment and research of osteoporosis patients in recent years, the genetic mechanism of osteoporosis has not yet been fully elucidated.

Methods

We conducted a comprehensive analysis using 16S sequencing and UHPLC-MS/MS metabolomics data to characterize the microbial composition and metabolic composition in the serum of osteoporosis patients.

Results

At the phylum level, Proteobacteria are mainly present in Osteoporosis; In Normal, it is mainly Bacteroidota. At the genus level, Cupriavidus is the main species in Osteoporosis; In Normal, the main ones are Blautia, Bacteroides, Alcaligenes and Pseudomonas. Serum metabolomics revealed different metabolites (2

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12504294 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature