Multi-pathway mechanisms of Liujunzi decoction in promoting glioma apoptosis and reversing drug resistance: network pharmacology and experimental validation.

ABSTRACT:

Background

Glioma is a highly aggressive brain tumor with a poor prognosis. Recent studies have demonstrated the anti-tumor potential of Liujunzi decoction (LJZD), but its specific effects and mechanisms in glioma remain unclear. This study aimed to elucidate the anti-glioma effects of LJZD and explore its underlying therapeutic mechanisms.

Methods

The active ingredients of LJZD were retrieved from the TCMSP database and screened using ADME analysis. Potential targets of both the ingredients and glioma were retrieved from various databases. The overlapping targets were identified as LJZD's therapeutic targets for glioma. To elucidate the biological functions and potential association among the overlapping targets, protein-protein interaction (PPI) network analysis, Gene Onto

SUBMITTER: Huang J 

PROVIDER: S-EPMC12504358 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature