Diagnostic and prognostic value of circulating biomarkers in heart failure.

ABSTRACT:

Background

Heart failure (HF) represents a global health burden with distinct phenotypes characterized by varying left ventricular ejection fraction (LVEF). Despite shared endothelial dysfunction, heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF) exhibit fundamentally different pathophysiological mechanisms, comorbidity profiles, and treatment responses.

Methods

This systematic review and meta-analysis examine inflammatory, cardiac remodelling and congestion, and myocardial injury biomarkers across HF phenotypes, integrating data from 78 studies encompassing 58,076 subjects.

Results

Our analysis reveals a significant elevation of IL-6, TNF-alpha, and hs-CRP in HF compared to controls, with distinct biomarker profiles emerging between phenotype

SUBMITTER: Kovenskiy A 

PROVIDER: S-EPMC12504382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature