A reappraisal of association between ventilator-associated events and mortality among critically ill patients using marginal structural model: multicenter observational study.

ABSTRACT:

Purpose

Ventilator-associated events (VAEs), developed by the US Centers for Disease Control and Prevention (CDC), are considered a new medical quality indicator associated with poor outcomes. However, previous studies failed to adjust for changes in patient severity, leaving open the possibility that VAEs are just a surrogate for severity. This study aimed to reevaluate the association between VAEs and mortality, adjusting for changes in severity over time.

Methods

This multicenter observational study was conducted in 18 ICUs in Japan between May 2020 and December 2022. Patients aged ≥ 12 years who received mechanical ventilation for ≥ 3 consecutive days were eligible. VAE was diagnosed according to the CDC definition. The primary outcome was 30-day in-hospital mortality, w

SUBMITTER: Nakahashi S 

PROVIDER: S-EPMC12504403 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature