Single-cell transcriptomic profiling reveals cell type heterogeneity between HFpEF and HFrEF.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) as a high heterogeneity clinical syndrome, is commonly associated with diastolic dysfunction, and has no effective therapy, which is obviously distinct from Heart failure with reduced ejection fraction (HFrEF). Currently the differences of cell type heterogeneity between HFpEF and HFrEF remain largely unknown. Here we illustrate an atlas consisting of 21,747 cardiac cells, including both HFpEF and HFrEF. Cell-cell communication analysis reveals cardiomyocytes rather than endothelium or fibroblasts were dominant communication "hub" in HFpEF. The subtypes of cardiomyocytes are highly heterogeneous between HFpEF and HFrEF. Notably, a specific subtype of cardiomyocytes shows significant gene expression associated with the metabolism of fat

SUBMITTER: Xiao X 

PROVIDER: S-EPMC12504458 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature